Recently, most mobile nodes, such as smartphones, will have multiple wireless radio interfaces. This feature allows a mobile node to access a multi-network through multiple wireless radio interfaces simultaneously. Accordingly, various networking technology has been studied to use wireless multi-interface more efficiently. In this paper, MPTCP based handover scheme is proposed to reduce data loss and end-to-end latency during the handover in PMIPv6 domain. The proposed scheme performs 2-step flow mobility on the multi-path established through the multi-interface of mobile node in the handover procedure and uses MPTCP subflow function to overcome end-to-end disconnection during the handover. Therefore, the proposed scheme takes the advantage of being able to minimize data loss and a latency generated during performing the handover of mobile node.