This paper examines the behaviour of two types of practical open beam-to-tubular column connection details subjected to combined moment, axial and/or shear loads. Detailed continuum finite element models are developed and validated against available experimental results, and extended to deal with flexural, axial and shear load interactions. A numerical investigation is then carried out on the behaviour of selected connections with different stiffness and strength characteristics under various load combination scenarios. The influence of applied levels of axial tensile or compressive loads on the bending stiffness and capacity is examined and discussed. Additionally, the interaction effects between shear forces and co-existing bending and axial loads are examined and shown to be comparatively insignificant in terms of stiffness and capacity in most cases. It is also shown that the range of connections considered in this paper can provide rotational ductility levels in excess of those required under typical design scenarios. Based on these findings, a simplified component-based representation is proposed and described, and its ability to represent the connection response under combined loading is verified using results from detailed numerical simulations.