Flow mixing and pressure drop characteristics for marine selective catalytic reduction applications were investigated numerically to develop an efficient static mixer. Two different mixers, line- and swirl-type, were considered. The effect of vane angles on the relative intensity, uniformity index, and pressure drop was investigated in a swirl-type mixer; these parameters are dramatically affected by the mixer geometry. The presence of a mixer, regardless of the mixer type, led to an improvement of approximately 20% in the mixing performance behind the mixer in comparison to not having a mixer. In particular, there was a tradeoff relationship between the uniformity and the pressure drop. Considering the mixing performance and the pressure drop, the swirl-type mixer was more suitable than the line-type mixer in this study.