In this paper, an algorithm using RGB-depth camera is proposed to detect smoke in interrior. RGB-depth camera, the Kinect provides RGB color image and depth information. The Kinect sensor consists of an infra-red laser emitter, infra-red camera and an RGB camera. A specific pattern of speckles radiated from the laser source is projected onto the scene. This pattern is captured by the infra-red camera and is analyzed to get depth information. The distance of each speckle of the specific pattern is measured and the depth of object is estimated. As the depth of object is highly changed, the depth of object plain can not be determined by the Kinect. The depth of smoke can not be determined too because the density of smoke is changed with constant frequency and intensity of infra-red image is varied between each pixels. In this paper, a smoke detection algorithm using characteristics of the Kinect is proposed. The region that the depth information is not determined sets the candidate region of smoke. If the intensity of the candidate region of color image is larger than a threshold, the region is confirmed as smoke region. As results of simulations, it is shown that the proposed method is effective to detect smoke in interior.