This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolata by stepwise steaming process and high pressure process. The phenol contents was $8.742{mu}g/mg$ which was higher than that from conventional extraction using 70% ethyl alcohol at $80^{circ}C$ for 24 hours. All of extracts at a concentration of $1.0mg/m{ell}$ showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cell growth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to $180{ imes}10^4cells/m{ell}$ and $96{ imes}10^4cells/m{ell}$, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-${alpha}$ from the stepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure process effectively released active biomaterials which could important role in enhancing immune activity in the body.