Effects of design variables on the performance of a double-inlet centrifugal blower have been analyzed based on the three-dimensional flow analysis. Two design variables, blade inlet and outlet angles, are introduced to enhance a blower performance. General analysis code, ANSYS-CFX13, is employed to analyze internal flow and a blower performance. SST turbulence model is employed to estimate the eddy viscosity. Throughout the shape optimization of an impeller at the design flow condition, the blower efficiency and pressure are successfully increased by 4.7 and 1.02 percent compared to reference one. It is noted that separated flow observed near cut-off region can be reduced by optimal design of blade angles, which results in stable flow pattern in the blade passage and increase of a blower performance. The stable flow at the impeller also makes good effects at the outlet of a volute casing.