This study focuses on analysis and comparison of entropy generation in various cross-sectional ducts along with fully developed laminar flow and constant uniform wall heat flux. The obtained results were compared in ducts with circular, semicircular, and rectangular with semicircular ends, equilateral triangular, and square and symmetrical hexagonal cross-sectional areas. These results were separately studied for aspect ratio of different rectangular shapes. Characteristics of fluid were considered at average temperature between outlet and inlet ducts. Results showed that factors such as Reynolds number, cross section, hydraulic diameter, heat flux and aspect ratio were effective on entropy generation, and these effects are more evident than heat flux and occur more in high heat fluxes. Considering the performed comparisons, it seems that semicircular and circular cross section generates less entropy than other cross sections.