After strong earthquakes conventional frames used worldwide in multi - story steel buildings (e.g. moment resisting frames) are not well positioned according to reparability. Two innovative systems for seismic resistant steel frames incorporated with dissipative fuses were developed within the European Research Program "FUSEIS" (Vayas et al. 2013). The first, FUSEIS1, resembles a vertical Vierendeel beam and is composed of two closely spaced strong columns rigidly connected to multiple beams. In the second system, FUSEIS2, a discontinuity is introduced in the composite beams of a moment resisting frame and the dissipative devices are steel plates connecting the two parts. The FUSEIS system is able to dissipate energy by means of inelastic deformations in the fuses and combines ductility and architectural transparency with stiffness. In case of strong earthquakes damage concentrates only in the fuses which behave as self-centering systems able to return the structure to its initial undeformed shape. Repair work after such an event is limited only to replacing the fuses. Experimental and numerical investigations were performed to study the response of the fuses system. Code relevant design rules for the seismic design of frames with dissipative FUSEIS and practical recommendations on the selection of the appropriate fuses as a function of the most important parameters and member verifications have been formulated and are included in a Design Guide. This article presents the design and performance of building frames with FUSEIS 1-1 based on models calibrated on the experimental results.