Purpose: The purpose of this research was to examine the effects of preferred music intervention on anxiety, vital signs and blood sugar of surgical patients undergoing spinal anesthesia. Methods: A quasi-experimental research with non-equivalent control group non-synchronized design was carried out. Subjects consisted of 40 patients (experimental group 20, control group 20) who were scheduled to undergo surgery with spinal anesthesia. During the operation, music individual patients preferred was provided to the experimental group. The data were collected from July 4 to November 10, 2011 and analyzed with descriptive statistics, t-test, chi-square test, ANCOVA and repeated measured ANCOVA using SAS (ver 9.2). Results: 1) Patient anxiety during the operation of the experimental group was significantly lower than the control group (F=93.77, p<.001). 2) There was no significant difference in diastolic blood pressure (F=.00, p=.979), Systolic blood pressure (F=.19, p=.668), heart rate (F=.00, p=.955), and blood sugar (F=.73, p=.399) between the experimental group and the control group. Conclusion: Letting patients hear their preferred music during surgery is an effective nursing intervention to relieve anxiety of patients undergoing surgery with spinal anesthesia.