The riser systems for floating offshore structures are known to experience tri-modal dynamic responses. These are owing to the combined loadings from the low-frequency response due to riser tension behavior, middle-range frequency response coming from winds and waves, and high-frequency response due to vortex induced-vibration. In this study, fatigue damage models were applied to predict the fatigue damages in a well-separated tri-modal spectrum, and the resultant fatigue damages of each model were compared with the most reasonable fatigue damage calculated by the inverse Fourier transform of the spectrum, rain-flow counting method, and Palmgren-Miner rule as a reference. The results show that the fatigue damage models developed for a wide-band spectrum are applicable to the tri-modal spectrum, and both the Benasciutti-Tovo and JB models could most accurately predict the fatigue damages of the tri-modal spectrum responses.