Over the past decade, an increasing number of manufactured nanoparticles (NPs) have been incorporated into products and manufacturing processes due to the rapid innovation and commercialization in the field of nanotechnology. In addition, these nanomaterials and nano-consumer products have increased in quantity per year, and thus their uncontrolled release into the environment is anticipated to grow dramatically in future. However, A current sewage/wastewater treatment plant (SWTP) is being applied to removal of nanoparticles in wastewater. In Korea, the study on the removal of nanoparticles in SWTP was not reported yet. Therefore, in this work, to design pilot STP before field test, two model equations and commercial process simulation were used to derive the desing parameters.