An experimental study was performed estimating COP(Coefficient of Performance) of air-conditioning cycle with inverter scroll compressor. All experiments were done for various compressor speeds from 1000~4000 rpm and used the inverter controller called CANDy to change the compressor rpm. The air-conditioning cycle components in the apparatus were used as same with components of YF hybrid car. To estimate the COP, this study measured the temperature and pressure at inlets and outlets of compressor, condenser, and evaporator. And also measured the compressor input power using Powermeter. Through the experiments, the maximum error to estimate COP was shown about ${pm}6.09%$ at 3500rpm. This study revealed that the condenser temperature and pressure were increased and the evaporator temperature and pressure were decreased with the increased compressor speed. And also, the COP was decreased with increased compressor speed. Those results can be used the basic and fundamental data to design the air-conditioning cycle with inverter scroll compressor.