In recent years, high-fidelity analysis tools, such as computational fluid dynamics and finite element method, have been widely used in multidisciplinary design optimization (MDO) to enhance the accuracy of design results. However, complex MDO problems have many design variables and require long computation times. Global sensitivity analysis (GSA) is proposed to assuage the complexity of design problems by reducing dimensionality where variables that have low impact on the objective function are neglected. This avoids wasting computational effort and time on low-priority variables. Additionally, uncertainty introduced by the fidelity of the analysis tools is considered in design optimization to increase the reliability of design results. Reliability-based design optimization (RBDO) and possibility-based design optimization (PBDO) methods are proposed to handle uncertainty in design optimization. In this paper, the extended Fourier amplitude sensitivity test was used for GSA, whereas a collaborative optimization-based framework with RBDO and PBDO was used to consider uncertainty introduced by approximation models. The proposed method was applied to an aero-structural design optimization of an aircraft wing to demonstrate the feasibility and efficiency of the developed method. The objective function was to maximize the lift-to-drag ratio. The proposed process reduced calculation efforts by reducing the number of design variables and achieved the target probability of failure when it considered uncertainty. Moreover, this work evaluated previous research in RBDO with MDO for the wing design by comparing it with the PBDO result.