Purpose: This study aimed to investigate the correlation between the health behaviors and the aggression in Korean high school students. Methods: This was a cross-sectional study conducted with a survey of 2,676 high school students. Aggression was measured in four categories (physical aggression, verbal aggression, anger and hostility) using the Aggression Questionnaire, a modified hostility inventory by Buss and Perry. Result: Univariate analysis showed that sex, smoking, alcohol, caffeine, pain pills and gastrointestinal drugs were significantly associated with aggression scores. Boys scored higher than girls in terms of physical and verbal aggression. With respect to the habit of self-medication, students who took pain pills in the last 30 days revealed higher scores in all four aggressive constructs. From multivariate analysis, it was found that alcohol, caffeine, smoking, pain pills, sex and gastrointestinal drugs were independently associated with total aggression score in the order of importance. Alcohol and caffeine, among these factors, had strong correlation with all aggressive characteristics. Conclusion: This study identified a consistent association between the aggression of the students and health behavioral factors, but causal relationship remains to be proven.