This study was conducted to evaluate the efficacy of benzobicyclon mixtures by using Remote-controlled aerial application (RCAA) to control annual and perennial weeds in rice paddy field. Eight annual weed species including Echinochloa crus-galli L. and three perennial weeds were dominated in the experimental field. Application of benzobicyclon mixtures using RCAA was highly effective to control both annual and perennial weed species. When compared with untreated control, no visual injuries were detected at single and double dosage of benzobicyclon mixtures. Finally, rice yield in the benzobicyclon mixtures was as much as that in the hand weeding. This study indicates that benzobicyclon mixtures using RCAA can be applied to control both annual and perennial weed species in rice paddy field.