A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (-)-sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on $TNF{alpha}$-induced NF-${kappa}B$ activation and transactivational activity of PPARs, including $PPAR{alpha}$, $PPAR{eta}({delta})$ and $PPAR{gamma}$ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on $TNF{alpha}$-induced NF-${kappa}B$ activation with $IC_{50}$ values of 5.50 and $8.10{mu}M$, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with $EC_{50}$ values of 47.12, 19.13 and $12.02{mu}M$, respectively. Among them, compound 4 demonstrated an increase in $PPAR{alpha}$ transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity.