Purpose: Smokeless tobacco-based oral-use products like gutka are popular in India. Gutka usage leads to increased periodontal destruction and inflammation; however, the relevant mechanism remains unknown. This study aimed to elucidate the role of gutka in periodontitis by examining its effect on the levels of interleukin (IL) $1{eta}$ and IL-8 from the gingival crevicular fluid (GCF). Methods: A total of 45 patients were enrolled in this study. Thirty patients with periodontitis (15 gutka chewers [GCP] and 15 nongutka chewers [NGC]) and 15 periodontally healthy controls (HC) were selected. The full-mouth plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and recession (RC) were recorded. The IL-$1{eta}$ and IL-8 levels in the GCF of all subjects were assessed through an enzyme-linked immunosorbent assay (Quantikine). Results: The IL-$1{eta}$ and IL-8 levels were not significantly higher in the GCP group (IL-$1{eta}$, $369.01{pm}273.44{mu}L$; IL-8, $205.97{pm}196.78{mu}L$) as compared to those in the NGC group (IL-$1{eta}$, $195.57{pm}96.85{mu}L$; IL-8, $178.61{pm}149.35{mu}L$). More gingival RC and loss of attachment was seen among the GCP group (RC: $2.02{pm}0.31$, P=0.013; CAL: $4.60{pm}0.56$, P<0.001) than among the NGC group (RC, $1.21{pm}1.15$; CAL, $3.70{pm}0.32$); however, PD was deeper among the NGC subjects (P=0.002). PI and GI were significantly higher for the periodontitis group (P<0.001) when compared to the HC, but there was no difference among gutka chewers and non-chewers (P=0.22 and P=0.89). A positive correlation was found between the IL-8 levels and the duration of gutka chewing (r=-0.64, P<0.01). Conclusions: Gutka chewing leads to increased gingival RC and clinical loss of attachment. There was no effect seen in the proinflammatory cytokine levels in the GCF of gutka users.