Purpose: The purpose of this study was to test hypothetical model of quality of life (QOL) in breast cancer survivors and to test the mediating effects of cognitive dysfunction. Methods: This study was conducted from December 1st, 2013 to February 28th, 2014. 164 breast cancer survivors were recruited from A, D, and Y city in Korea. The instruments used in this study were climacteric symptoms, fatigue, cognitive dysfunction, and the QOL scales. Data were analyzed using descriptive statistics, correlation, and pathway. Results: Cognitive dysfunction was directly affected by climacteric symptoms and fatigue. QOL was directly affected by fatigue, However climacteric symptoms and cognitive dysfunction did not effect on QOL directly. Impact of climacteric symptoms on QOL, mediating effect of cognitive dysfunction was not confirmed. In addition, effect of fatigue on the QOL, the mediating effect of cognitive dysfunction was not. Conclusions: Effects of climacteric symptoms on QOL was not mediated by cognitive dysfunction, Furthermore effects of fatigue on QOL was not mediated by cognitive dysfunction.