This paper introduces a refined opportunistic interference alignment (OIA) technique that uses minimum mean square error (MMSE) detection at the receivers in multiple-input multiple-output multi-cell uplink networks. In the OIA scheme under consideration, each user performs the optimal transmit beamforming and power control to minimize the level of interference generated to the other-cell base stations, as in the conventional energy-efficient OIA. The result showed that owing to the enhanced receiver structure, the OIA scheme shows much higher sum-rates than those of the conventional OIA with zero-forcing detection for all signal-to-noise ratio regions.