We proposed a design method for squib current supply & interlock circuits in guided-missile fire control systems. In order to design squib current supply circuits, various missile squib loads including line resistance and squib devices have to be considered in advance minimizing probability of redesign of circuits and reducing the development cost by implementing the most proper squib current supply circuit. Also, we presented a hardware interlock logic instead of the commonly used software safety logic to improve the safety of guided-missile fire control systems. The proposed squib interlock circuit enhances safety requirements of guided-missile fire control systems. We confirmed that simulation and measurement results of the proposed design method are the same as theoretical analysis results.