Purpose: This study aimed at providing guidelines and educational manuals on infection control for the home care environment, by assessing the knowledge and performance among the caregivers in home care. Methods: Data were collected from January to March 2013. Participants were 172 caregivers who were registered in the home nursing center of university hospitals. Results: The total score on the level of knowledge of infection control was 13.28 points (${pm}3.49$) out of 20 points. Secondly, 4.15 points were obtained for individual hygiene management, 4.14 points for hand wash, and 3.86 points for environment management. Lastly, the relationship between the knowledge and performance of infection control showed a significant positive correlation (r=0.37, p<.001). Conclusion: In many instances, the caregivers in the home environment provide nursing care for patients with chronic diseases and make use of various invasive devices. This study recommends the development of a manual or educational guidelines on infection control that can be used by caregivers at the home.