This study aimed at examining the anti-inflammatory effects of Scutellariae Radix & Lonicerae Caulis water extract(SC). RAW 264.7 mouse macrophage cells were treated with $25{sim}200{mu}g/m{ell}$ SC for 24 hours. Cell viability was then measured using MTT assays. The nitric oxide(NO) production and the creation of several cytokines in LPS-stimulated RAW 264.7 cells were investigated. SC inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50 and $200{mu}g/m{ell}$. SC inhibited significantly the TNF-${alpha}$ of the RAW 264.7 cell induced by LPS at the density of $50{mu}g/m{ell}$. SC inhibited significantly the MIP-$1{alpha}$ of the RAW 264.7 cell induced by LPS at the density of 25, 50 and $100{mu}g/m{ell}$. SC inhibited significantly the MIP-$1{eta}$, MIP-2 at the density of 50, $100{mu}g/m{ell}$ in the RAW 264.7 cell increased by LPS, respectively. SC did not affect the production levels of VEGF in RAW 264.7 cell. As a result, SC significantly inhibited the inductions of MIP-$1{alpha}$, MIP-$1{eta}$, MIP-2 and NO in LPS-induced RAW 264.7 cell without causing the toxicity. These results signify that SC has anti-inflammatory effects on controlling the over inflammatory reaction on the RAW 264.7 cell.