In this paper, the numerical simulation of the gas-liquid flow in a cylinder cyclone separator is performed to investigate the flow characteristics using a commercial software, FLUENT, which solves the Reynolds-averaged Navier-Stokes(RaNS) equations. First, a single-phase flow with water in a gas-liquid cylinder cyclone(GLCC) separator is simulated and compared with the experiments(Farchi, 1990) and numerical simulations(Erdal, 1997). Then, the characteristics of the multi-phase flow for water-air, mud-only, and mud-air cases are discussed in the view point of the feasibilities for a mud handling system.