This study synthetically investigated the relationship between social support and ego resilience, job satisfaction of the public health center workers providing medical service to local residents at the front. Unlike previous researches, this study took all variables of social support, ego resilience and job satisfaction into account, moreover, regarded it as important to verify mediated effect of ego resilience through influencing relationship between social support and job satisfaction. At the result of actual proof analysis via surveys, the social support of the public health center workers indicated the mediated effect on ego resilience and job satisfaction, besides, ego resilience influenced on job satisfaction and the mediated effect of ego resilience was also shown. Therefore, this study emphasized importance of the psychological satisfaction for the public health center workers as to provide residents better medical service based on the empirical testing result.