In this paper, the performance characteristics of R404 indirect refrigeration system using R744 as a secondary refrigerant were investigated experimentally to obtain a optimum design data for this system. First, for the constant experimental conditions, the COP of R404A indirect refrigeration system using R744 as secondary refrigerants decreases with respect to the increases in R404A condensation temperature and temperature difference in R744 cooler. And, the COP of indirect refrigeration system using R744 as secondary refrigerants decreases slightly with decreasing the mass flowrate of R744.