In this study, we explored the factors related with preference for and participation in science-related activities of elementary school students. We developed a questionnaire to measure the characteristics of students such as motivation toward science learning, science aspiration, family science orientation, parental educational level and occupation, and the degrees of preference and participation of science-related activities. The questionnaire was administered to about 400 fourth graders in Seoul. The results revealed that the students with higher motivation toward science learning and/or science aspiration preferred and participated more in most activities. It was also found that parental educational level and occupation did not make an appreciable difference in preference and participation. The students who perceived their parents to be science-oriented, however, preferred and participated more in most activities. These results may offer practical implications for effective uses of both school and out-of-school science activities in elementary science education.