Recently, in power system studies, Multiple Energy Carriers (MECs) such as Energy Hub has been broadly utilized in power system planners and operators. Particularly, Energy Hub performs one of the most important role as the intermediate in implementing the MECs. However, it still needs to be put under examination in both modeling and operating concerns. For instance, a probabilistic optimization model is treated by a robust global optimization technique such as multi-agent genetic algorithm (MAGA) which can support the online economic dispatch of MECs. MAGA also reduces the inevitable uncertainty caused by the integration of selected input energy carriers. However, MAGA only considers current state of the integration of selected input energy carriers in conjunctive with the condition of smart grid environments for decision making in Energy Hub. Thus, in this paper, we propose an immune algorithm based Multiple Energy Carriers System which can adopt the learning process in order to make a self decision making in Energy Hub. In particular, the proposed immune algorithm considers the previous state, the current state, and the future state of the selected input energy carriers in order to predict the next decision making of Energy Hub based on the probabilistic optimization model. The below figure shows the proposed immune algorithm based Multiple Energy Carriers System. Finally, we will compare the online economic dispatch of MECs of two algorithms such as MAGA and immune algorithm based MECs by using Real Time Digital Simulator (RTDS).