In this paper, we present an alternative seismic design strategy for cable stayed bridges with concrete pylons when subjected to strong ground motions. The comparison of conventional seismic design using supplemental dampers (strategy A) and the new strategy using nonlinear seismic design of pylon columns (strategy B) is exemplified by one typical medium span cable stayed bridge subjected to strong ground motions from 1999 Taiwan Chi-Chi earthquake and 2008 China Wenchuan earthquake. We first conducted the optimization of damper parameters according to strategy A in response to the distinct features that strong ground motions contain. And then we adopted strategy B to carry out seismic analysis by introducing the elastic-plastic elements that allowing plasticity development in the pylon columns. The numerical results show that via strategy A, the earthquake induced structural responses can be kept in the desired range provided with the proper damping parameters, however, the extra cost of unusual dampers will be inevitable. For strategy B, the pylon columns may not remain elastic and certain plasticity developed, but the seismic responses of the foundation will be greatly decreased, meanwhile, the displacement at the top of pylon seems to be not affected much by the yielding of pylon columns, which indicates the pylon nonlinear design can be an alternative design strategy when strong ground motions have to be considered for the bridge.