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A modified partial least squares regression for the analysis of gene expression data with survival information
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  • A modified partial least squares regression for the analysis of gene expression data with survival information
  • A modified partial least squares regression for the analysis of gene expression data with survival information
저자명
Lee. So-Yoon,Huh. Myung-Hoe,Park. Mira
간행물명
한국데이터정보과학회지
권/호정보
2014년|25권 5호|pp.1151-1160 (10 pages)
발행정보
한국데이터정보과학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In DNA microarray studies, the number of genes far exceeds the number of samples and the gene expression measures are highly correlated. Partial least squares regression (PLSR) is one of the popular methods for dimensional reduction and known to be useful for the classifications of microarray data by several studies. In this study, we suggest a modified version of the partial least squares regression to analyze gene expression data with survival information. The method is designed as a new gene selection method using PLSR with an iterative procedure of imputing censored survival time. Mean square error of prediction criterion is used to determine the dimension of the model. To visualize the data, plot for variables superimposed with samples are used. The method is applied to two microarray data sets, both containing survival time. The results show that the proposed method works well for interpreting gene expression microarray data.