In the recent times, dimensions of heavy load carrying vehicle have changed significantly incorporating structural flexibility in vehicle body. The present paper outlines a procedure for the estimation of bridge response statistics considering structural bending modes of the vehicle. Bridge deck roughness has been considered to be non homogeneous random process in space. Influence of pre cambering of bridge surface and settlement of approach slab on the dynamic behavior of the bridge has been studied. A parametric study considering vehicle axle spacing, mass, speed, vehicle flexibility, deck unevenness and eccentricity of vehicle path have been conducted. Dynamic amplification factor (DAF) of the bridge response has been obtained for several of combination of bridge-vehicle parameters. The present study reveals that flexible modes of vehicle can reduce dynamic response of the bridge to the extent of 30-37% of that caused by rigid vehicle model. However, sudden change in the bridge surface profile leads to significant amount of increment in the bridge dynamic response even if flexible bending modes remain active. The eccentricity of vehicle path and flexural/torsional rigidity ratios plays a significant role in dynamic amplification of bridge response.