The stress between work piece and end mill at the use of end mill at machining and the structural deformation due to the and the pressure are investigated by simulation analysis of three end mill models in this study. These results are achieved with structural and fatigue analyses. Model 1 has the deformation less than model 2 or model 3. As the maximum equivalent stress of model 1 is shown to become the least among all models, model 1 can endure the highest load by comparing with other models. It is useful to estimate the damage prevention and the durability by applying this study result into the design of end mill.