PFA fluoropolymer lined technology revolutionized ball valve development and design decades ago and continues to be pivotal for many products and valve solutions in diverse industries and applications, such as chemical process, semiconductor/LCD manufacturing processes, pharmaceutical and others. Because of the extreme operating conditions such as high-temperature (${sim}120^{circ}C$) and high-pressure (~10 bar), the reliability of the valve is very important for minimizing in-line leakage and fugitive emissions of strong corrosive chemicals (hydrochloric acid, hydrofluoric acid, nitric acid, etc.) transported through the lines. In this study, we investigated the flow characteristics with flow coefficient in a PFA lined ball valve for different opening degrees using CFD analyses. The results should be the guidance for a new PFA lined ball valve design that will incorporate all the acclaimed and demonstrated benefits of the current design approaches.