In this paper, to systematically assess the abandonment risk of main control room (MCR) fire, fire simulations with Fire Dynamics Simulator were performed and abandonment probabilities were estimated for the MCR bench-board fire of domestic reference nuclear power plant. The fire simulation scenarios performed in this study included propagating and non-propagating fires of the MCR bench-board, and the availability and unavailability of heating, ventilation, and air conditioning system (HVACS). The following results were obtained. First, temperature was the major abandonment impact factor for the MCR bench-board fire if the HVACS was available and optical density was that if the HVACS was unavailable. Second, the fire scenario contributing the MCR bench-board fire abandonment risk was identified to be only the propagating fire. Third, it was confirmed that the abandonment probability of the MCR bench-board fire for domestic reference nuclear power plant could be reduced by using the fire modeling.