For the safe handling of n-hexadecane, the lower flash points and the upper flash point, fire point, AITs(auto-ignition temperatures) by ignition delay time were experimented. Also lower and upper explosion limits by using measured the lower and upper flash points for n-hexadecane were calculated. The lower flash points of n-hexadecane by using the Setaflash and the Pensky-Martens closed testers were measured $128^{circ}C$ and $126^{circ}C$, respectively. The lower flash points of the Tag and the Cleveland open cup testers were measured $136^{circ}C$ and $132^{circ}C$, respectively. The fire points of the Tag and the Cleveland open cup testers were measured $144^{circ}C$. respectively. This study measured relationship between the AITs and the ignition delay times by using ASTM E659 apparatus for n-hexadecane. The experimental AIT of n-hexadecane was $200^{circ}C$. The calculated lower and upper explosion limit by using measured lower $128^{circ}C$ and upper flash point $180^{circ}C$ for n-hexadecane were 0.42 Vol.% and 4.70 Vol.%.