Recently a new version of PRO-LOCA program was released. Using the program, failure probability of pipes can be evaluated considering fatigue and/or stress corrosion crack growth and the effects of various parameters on the integrity of pipes in nuclear power plants can be evaluated quantitatively. The analysis results can be used to establish an inspection plan and to examine the effects of important parameters in a maintenance plan. In this study, sensitivity analyses were performed using the program for several important parameters including sampling method, initial crack size, number of initial fabrication flaws, operation temperature, inspection interval, operation temperature and nominal applied bending stress. The effect of parameters on the leak and rupture probability of pipes was evaluated due to fatigue or stress corrosion crack growth.