Proxies for paleo-circulation are drawing much interest with the recognition that ocean circulation plays an important part in the redistribution of heat and climate change on orbital and millennial timescales. In this review, we will introduce how neodymium isotope ratios of the authigenic fraction of marine sediments can be used as a proxy for ocean circulation along with analytical methods and two case studies. The first case study shows how the North Atlantic Deep Water (NADW) has varied over the glacial-interglacial and stadial-interstadial periods. The second case study shows how the freshwater budget and water circulation within the Arctic Ocean can be reconstructed for the last glacial period.