This paper dealt with numerical estimation of the pressure pulsation of the refrigerant in a suction pipe of the compressor. The behavior of the pressure pulsation was assumed to satisfy the wave equation. The boundary conditions and properties of refrigerant are necessary as input data of the simulation. The pulsating pressures at 15 points in a pipe were measured simultaneously from the pressure transducers. From the experimental data, the complex phase speed and impedance at the end of the pipe of the refrigerant were estimated using the signal processing and used as the input conditions of the numerical analysis. A commercial acoustic software was used to solve the behavior of pressure pulsation. The numerical results for the pressure pulsation in a pipe with and without expansion chamber were carried out and compared with those by experiments. Finally, numerical procedure to estimate the pressure pulsation in a pipe was established and verified.