With the explosive increase of esthetic demands by patients, many dental materials for the esthetic restoration have been introduced. Recently, zirconia based restorations are using for the cases of single crown, bridges, implant prostheses etc. Zirconia have superior mechanical properties and biocompatibility. Owing to the properties of high strength, zirconia has to be manufactured by CAD/CAM system. Dental CAD/CAM system is a futuristic treatment and technical system which makes it possible to produce the precision and uniform prosthesis and also standardize the treatments. This article introduces the characteristics of zirconia, fabrication procedure using CAD/CAM system and procedure for the cementation of zirconia based restoration.