In this paper, a generalized power loss algorithm for multilevel neutral-point clamped (NPC) PWM inverters is presented, which is applicable to any level number of multilevel inverters. In the case of three-level inverters, the conduction loss depends on the MI (modulation index) and the PF (power factor), and the switching loss depends on a switching frequency, turn-on and turn-off energy. However, in the higher level of inverters than the three-level, the loss of semiconductor devices cannot be analyzed by conventional methods. The modulation depth should be considered in addition, to find the different conducting devices depending on the MI. In a case study, the power loss analysis for the three- and five-level NPC inverters has been performed with the proposed algorithm. The validity of the proposed algorithm is verified by simulation for the three-and five-level NPC inverters and experiment for three-level NPC inverter.