The purpose of this study was to predict the load effect on a damper installed at a nuclear power plant building after a tsunami using a volume of fluid (VOF) numerical analysis method. The wave height was determined by a sine wave function and the tsunami condition was estimated by the wave length. Also, using computational fluid dynamics (CFD), the maximum damper load was set as a boundary condition for the structural analysis that verified how stress and deformation affect the damper. As a result, such simulations estimated the highest stress distribution for a wave length of 350 m with a maximum stress present at the cross point of stiffness installed at the rear end of the damper. The total deformation was approximately 32 mm at the center of damper.