Pleomorphic adenoma is the most common benign mixed salivary gland neoplasm that accounts for 65% of all benign salivary glands tumors. While the majority arises from the parotid, only a 10% arises from the minor salivary glands. Pleomorphic adenoma of minor salivary gland in the palate is a common entity. However, they occur in the lip, cheek, tongue oropharynx and nasal cavity etc., rarely. We experienced a case of a 80 years old female presented a 10 years history of a right cheek mass which was proved to the pleomorphic adenoma on the histopathologic examination. We resected the mass and obtained good postoperative results. We report this case with a review of literature.