In this paper, an Adaptive nerou-based inference system (ANFIS) is being used for the prediction of shear strength of high strength concrete (HSC) beams without stirrups. The input parameters comprise of tensile reinforcement ratio, concrete compressive strength and shear span to depth ratio. Additionally, 122 experimental datasets were extracted from the literature review on the HSC beams with some comparable cross sectional dimensions and loading conditions. A comparative analysis has been carried out on the predicted shear strength of HSC beams without stirrups via the ANFIS method with those from the CEB-FIP Model Code (1990), AASHTO LRFD 1994 and CSA A23.3 - 94 codes of design. The shear strength prediction with ANFIS is discovered to be superior to CEB-FIP Model Code (1990), AASHTO LRFD 1994 and CSA A23.3 - 94. The predictions obtained from the ANFIS are harmonious with the test results not accounting for the shear span to depth ratio, tensile reinforcement ratio and concrete compressive strength; the data of the average, variance, correlation coefficient and coefficient of variation (CV) of the ratio between the shear strength predicted using the ANFIS method and the real shear strength are 0.995, 0.014, 0.969 and 11.97%, respectively. Taking a look at the CV index, the shear strength prediction shows better in nonlinear iterations such as the ANFIS for shear strength prediction of HSC beams without stirrups.