This study intended to analyze picture books and activity contents of Book Start Program targeting infants and preschooler. Target objects were 244 picture books with their activities contained on casebook of Book Start Program. First, the study outcome showed that the most type of its picture books in general was fantasy, while, by ages, play books for those in 6~18 months, information books for those in 19~35 months, and fantasy books for those in 36 months~before going to school were the most. Second, contents of the picture books showed the most order of nature exploration, social relationship, art experience, while by ages, contents on nature exploration were the most in all ages, while social relationship and art experience showed statistically significant difference by ages. Third, the outcome of activity contents utilizing the books showed drawing activities were the most, while activities other than drawing showed statistically significant difference by ages. This result shows that they chose a picture book suitable for the developmental characteristics of the infants and preschoolers, but that the contents of the picture book were not closely associated with the activities. The outcome of this study lies in offering information and basis on ways to choose effective picture books and their activities to those planning and running Book Start Program in the future.