In this paper we introduce the notion of the generalized Darbo fixed point theorem and prove some fixed and coupled fixed point theorems in Banach space via the measure of non-compactness, which generalize the result of Aghajani et al. [6]. Our results generalize, extend, and unify several well-known comparable results in the literature. One of the applications of our main result is to prove the existence of solutions for the system of integral equations.