This paper identifies the effects of infill wall existence and arrangement in the seismic response of steel frame structures. The methodology followed was based on the utilisation of overall seismic response indicators that distil the complexity of structural response in a single value hence enabling their straightforward comparative and statistical post process. The overall structure damage index after Park/Ang ($OSDI_{PA}$) and the maximum inter-story drift ratio (MISDR) have been selected as widely utilized structural seismic response parameters in contemporary state of art. In this respect a set of 225 Greek antiseismic code (EAK) spectrum compatible artificial accelerograms have been created and a series of non-linear dynamic analyses have been executed. Data were obtained through nonlinear dynamic analyses carried on an indicative steel frame structure with 5 different infill wall topologies. Results indicated the significant overall contribution of infill walls with a reduction that ranged 35-47% of the maximum and 74-81% of the average recorded $OSDI_{PA}$ values followed by an overall reduction of 64-67% and 58-61% for the respective maximum and average recorded MISDR values demonstrating the relative benefits of infill walls presence overall as well as localised with similar reductions observed in 1st level damage indicators.