Based on scrupulous examination of major neuroscience theories and research results, this study purports
to inquire a scientific foundation of motivational strategies design that could overcome various pitfalls
caused by neuromyths. Cognitive neuroscience and cognitive neuropsychology have unearthed scientifically
brain structure and cognitive process related to learning activities, performing the research that looks deep
into active brain actually responding to instruction-learning situations. In this respect, the brain-based
research about learning motivation could provide an scientific cornerstone for instructional treatment
contributing to better education. Therefore, on the basis of systematic comparative analysis on motivational
strategies of major brain-based instructional models, researcher for this study tries to investigate a
foundation in terms of theory and practice that could effectively integrate with future instructional
framework. The results of the comparative research are as follows: The brain-based motivational
methodologies are 1) learning environment beyond instructional strategies, 2) on-going process applicable to
whole procedure of instruction, 3) systemic provision of intrinsic and extrinsic motivation, 4) offering
differential tactics in accordance with focused theoretical basis, 5) searching for the appropriate strategies
according to characteristics of applicable educational settings, 6) mutually integrative and complementary. In
this regard, this study describes peculiarities and instruction-learning implications of specific motivational
strategies in accordance with the results of the analysis, comparing concomitantly other existent motivation
theories.