The present study aimed to test the mediation effect of mindfulness in the relationship between perfectionism and academic burnout. The participants were 288 high school students, and structural equation modeling was used for the mediation analysis. The results indicated that high self-oriented perfectionism was associated with high mindfulness and low burnout. On the other hand, socially prescribed perfectionism were associated with low mindfulness and high burnout. The mediating effect of mindfulness was significant in the exhaustion among three sub-scales of burnout. It means that mindfulness mediates the effect of self-oriented perfectionism and socially prescribed perfectionism on exhaustion. In conclusion, self-oriented perfectionism was associated with adaptive functioning which increases mindfulness and decreases burnout, whereas socially prescribed perfectionism was associated with maladaptive functioning which decreases mindfulness and increases burnout.