The purpose of this study is to examine and verify the mediating effects of alexthymia and maladaptive cognitive emotion regulation in relation to childhood abuse and late adolescent depression. For this study, the questionnaires containing the Childhood Trauma Questionnaire Short Form, Center for Epidemologic Studies Depression Scale, the Cognitive Emotion Regulation Questionnaire, and the Item Toronto Alexithymia Scale were administered to 375 college students recruited from universities located in Seoul and Gyeonggi area. The major findings were as follows: First, child abuse, maladaptive cognitive emotion regulation strategy, and alexthymia showed positive correlations with late adolescent depression. Second, in the process of examining the mediating effects of maladaptive cognitive emotion regulation strategy and alexthymia, the research gave evidence that alexthymia partially mediated while maladaptive cognitive emotion regulation strategy had no mediative effect. These results may contribute to better understanding of the relation between childhood abuse and late adolescent depression. Also, the results can suggest emotional approach for clinicians who want to reduce patients’ depression.