The present clinical study was undertaken to evaluate the implant stability, marginal bone change and the survival rate of DIO® SM submerged internal-type implants placed at the partially edentulous posterior missing area. In this prospective study, 72 patients treated with 111 DIO® SM submerged internal-type implants placed at the posterior maxilla or mandible after loss of single or multiple teeth were included. The ISQ (implant stability quotient) value was measured after the first and second implant surgeries (three months apart) using Osstell Mentor. After prosthodontic rehabilitation, a PTV (periotest value) test was performed to check implant stability. Marginal bone loss was assessed using periapical film taken with a standardized technique with XCP device at three month intervals (range: 3- 24 months). No implants were removed during follow up, yielding a 24-month cumulative survival rate of 100%. The average value of the implant fixtures (ISQ) was 69.95±8.04 at the immediate installation and 74.18±8.22 at the second surgery. The ISQ discrepancy between the two visits was 3.59±7.62. Finally, the PTV was steady at 0.5-1. The average marginal bone loss (MBL) was 0.25± 0.22mm for all implants at three months, 0.45±0.31mm at six months, 0.67±0.44mm at nine months, 0.70±0.42mm at 12 months and 0.68±0.46mm at 15 months. The success rate was 97.30%. The DIO® SM implants exhibited the desired consequences over a short period with regard to the implant stability, marginal bone loss and success rate. A prospective single arm clinical trial demonstrated a low frequency of progressive bone loss, stable implant stability, and 100% success rate. [THE JOURNAL OF THE KOREAN ACADEMY OF IMPLANT DENTISTRY 2010;29(1):71-78]