The purpose of this study was to investigate how ‘STS science class’ linked with vocation effects on science knowledge, career attitude and science education attitude of college with developmental disabilities(DD). 33 students with DD, 2nd grade 24 and 3rd grade 9 in N university, in exploring vocation class, participated in this study which include surveys and interviews. This study was one-group pretest-posttest design. A descriptive statistics and t-test approaches were used to investigate the general information and the difference between the pretest and posttest. It was employed to analyze correlation between career attitude and science education attitude by SPSS(VER.20) and Interviews by constant comparative method. The finding of this study is as follows. First, scientific knowledge achievement of students with DD was improved. Second, students with DD show better awareness about career attitude and scientific education attitudes. Third, the correlation between career attitude and scientific education attitude was also statistically significant. Finally, although scientific knowledges required cognitive competences, this study show that science education on STS class-model linked with vocation can improve achievements of students with DD on scientific knowledge. These findings further suggest that functional educational curriculum linked with real life like STS model should be more invigorated on educations of college students with DD.